Description:
FDI 6 is an inhibitor of the Forkhead box protein M1 transcription factor (FOXM1) (IC50 value 22.5 µM) that suppresses FOXM1 binding to DNA. FDI6 displaces FOXM1 from genomic targets in MCF-7 breast cancer cells, and downregulates concomitant transcription.
- Molecular Weight:437.43
- Purity:99%
Molecular Formula:
C19H11F4N3OS2
Canonical SMILES:
C1=CSC(=C1)C2=NC3=C(C(=C2)C(F)(F)F)C(=C(S3)C(=O)NC4=CC=C(C=C4)F)N
InChI:
InChI=1S/C19H11F4N3OS2/c20-9-3-5-10(6-4-9)25-17(27)16-15(24)14-11(19(21,22)23)8-12(26-18(14)29-16)13-2-1-7-28-13/h1-8H,24H2,(H,25,27)
InChIKey:
ZATJMMZPGVDUOM-UHFFFAOYSA-N
Synonyms:
FDI-6; FDI 6; FDI6; NCGC00099374; NCGC-00099374; NCGC 00099374; 3-amino-6-thiophen-2-yl-4-trifluoromethyl-thieno[2,3-b]pyridine-2-carboxylic acid (4-fluoro-phenyl)-amide; 3-amino-N-(4-fluorophenyl)-6-(2-thienyl)-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxamide; 3-amino-N-(4-fluorophenyl)-6-(thiophen-2-yl)-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxamide; AC1NPA9B Más detalles se encuentran
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